| Rank | Companies |
| 1 | Woodloch Pines |
| 2 | Lehigh Valley Hospital and Health Network |
| 3 | East Penn Manufacturing |
| 4 | Sheetz |
| 5 | Cozen O'Connor |
| 6 | DuBois Regional Medical Center |
| 7 | Memorial Hospital |
| 8 | Home Nursing Agency |
| 9 | American Infrastructure |
| 10 | St. Clair Hospital |
| 11 | Fulton Bank |
| 12 | New Pig Corporation |
| 13 | Pennoni Associates |
| 14 | Wenger's Feed Mill |
| 15 | The PMA Insurance Group |
| 16 | PSECU |
| 17 | Benco Dental Company |
| 18 | Blue Ball National Bank |
| 19 | Waynesboro Hospital |
| 20 | National Penn Bancshares |
| 21 | Teva Pharmaceuticals |
| 22 | Enterprise Rent-A-Car |
| 23 | SYSCO Food Services of Central Pennsylvania |
| 24 | Quality Custom Cabinetry |
| 25 | Worth & Company |
| 26 | Gettysburg College |
| 27 | McCormick Taylor |
| 28 | Butler Memorial Hospital |
| 29 | PJM Interconnection |
| 30 | Blue Cross of Northeastern Pennsylvania |
| 31 | Concurrent Technologies Corporation (CTC) |
| 32 | The Children's Hospital of Philadelphia |
| 33 | St. Luke's Hospital |
| 34 | The Horst Group |
| 35 | Moravian Manors |
| 36 | Pride Mobility Products |
| 37 | Lancaster Laboratories |
| 38 | PinnacleHealth System |
| 39 | Cornwall Manor |
| 40 | L. Robert Kimball & Associates |
| 41 | Hamot Medical Center |
| 42 | Playworld Systems Incorporated |
| 43 | 84 Lumber Company |
| 44 | The Jay Group |
| 45 | Select Medical Corporation |
| 46 | Pennfield Corporation |
| 47 | Holy Spirit Health System |
| 48 | Hoss's Restaurant Operations |
| 49 | Independence Blue Cross |
| 50 | Lancaster General |
